Diffuse low-grade gliomas

, by  Hugues DUFFAU , popularity : 10%
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Better knowledge of the natural history of DLGG (growth, infiltration and inevitable degeneration) associated with a risk minimization of each treatment has transformed the ’classic’ abstentionist attitude into a resolutely therapeutic attitude.

The goal from now on is towards the development of dynamic and tailored strategy for each patient, namely to determine the sequence and timing of each treatment (single to multiple safe maximal surgical resections within cortical-to-sub-cortical functional borders or single to multiple chemotherapy and radiotherapy sessions) depending on the tumor progression (measured on regular follow up MRI scan), and the clinical and neuropsychological condition and functional brain anatomy of the individual (studied by brain mapping methods and capable of reorganizing through the mechanisms of neuroplasticity) so as to prevent malignant transformation as long as possible while preserving the quality of life.

Only a multidisciplinary approach to multi-center networks can afford to give a real future to patients with this chronic brain disease, with the possibility to design long-term projects be them socio-professional as well as at household level- especially those with plans to become pregnant. The next step would be that of early screening in order to provide preventive treatment(49)..


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